Lytton First Nation is located on 14,161 acres of land divided into 56 reserves. The reserves are located at the site of the Indian Village of Kumsheen, meaning "where the Rivers Cross". Commissioner O'Reilly allotted the reserves on August 24, 1881.

Geographically located along the Trans-Canada Highway, between the towns of Hope and Cache Creek, the Lytton First Nation reserves are scattered along a 100-killometer radius on both sides of the Fraser River.

Lytton First Nation is rich in natural resources. Water availability is perhaps one of the most significant natural resources available to the Nation. The Stein River water system meets the water needs of a large proportion of community members while other community wells provide water to other members. Natural spring waters are available in various areas.